Mathias Tiedemann Svendsen

MD, PhD-student
Department of Dermatology and Allergy Centre

Medical adherence in patients diagnosed with psoriasis treated with prescribed topical corticosteroids or corticosteroid/calcipotriol combinations

Factors determining nonadherence, patterns of nonadherence, and a designed patient-centered intervention to improve adherence

Psoriasis is a common skin disease with an estimated prevalence of 2-3 %. Psoriasis is associated with comorbidities, such as arthritis, depression, cardiovascular, and metabolic diseases. The individual patient has a high burden of disease and need for continuous treatment.

Patients experience a significant negative impact on quality of life and face obstacles using medications with potential side-effects. The motivation to adhere to the doctor treatment-plan vary between patients and low rates of adherence result in poor treatment outcome. Based on a literature review, it is estimated that about 50% of psoriasis patients do not adhere to prescribed topical treatments.   

Centre for Innovative Medical Technology (CIMT), Department of Dermatology and Allergy Center, Odense University Hospital, and Leo Pharma have established a co-operation with the aim to investigate if a patient-centered supporting app for smartphones, can improve adherence to topical treatments.

Results from this project can be used in the treatment of other chronic dermatoses.

Study elements:

  1. Systematic literature review, describing the determinants of adherence in topically treated psoriasis.

  2. Qualitative study, describing determinants of nonadherence, e.g. economy, misunderstandings, forgetfulness, side effects, lack of awareness, understanding and accept of own disease, and lack of support.

  3. Register-based national study, describing patterns of use and rates of nonadherence to treatments with topical corticosteroids.

  4. Interventional study, testing if an app for smartphones can improve rates of adherence to topical treatments. In addition, the study investigates if improved rates of adherence lead to reduced severity of psoriasis and improved quality of life.

Main supervisors:

Professor, D.Msci., Klaus Ejner Andersen, Department of Dermatology and Allergy Centre, OUH and Centre for Innovative Medical Technology, Institute of Clinical Research, University of Southern Denmark.

Consultant, PhD, Flemming Andersen, Department of Dermatology and Allergy Centre, OUH

Associate supervisors:

Professor, Head of Research Unit, Mag.scient, PhD, Helle Johannessen, Research Unit of User Perspectives, Department of Public Health, University of Southern Denmark, DK-5000 Odense C, Denmark

Postdoc, PhD, Anton Pottegård, Clinical Pharmacology, Department of Public health, University of Southern Denmark, DK-5000 Odense C, Denmark

Global scientific advisor  Dr. Benjamin August, Leo Pharma



Mathias Tiedemann Svendsen, Flemming Andersen, Jakob Hansen, Helle Johannessen & Klaus Ejner Andersen (2016): Medical adherence to topical corticosteroid preparations prescribed for psoriasis: A systematic review, Journal of Dermatological Treatment

Mathias Tiedemann Svendsen, Klaus Ejner Andersen, Flemming Andersen, Jakob Hansen, Anton Pottegård, Helle Johannessen (2016). Psoriasis patients’ experiences concerning medical adherence to treatment with topical corticosteroids. Psoriasis: Targets and Therapy 

Mathias Tiedemann Svendsen, Janithika Jeyabalan, Klaus Ejner Andersen, Flemming Andersen, Helle Johannessen (2016): Worldwide Utilization of Topical remedies in Treatment of Psoriasis: A Systematic Review, Journal of Dermatological Treatment

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